Hyaluronic Acid

Hallmarks of aging We propose the following 11 hallmarks of aging: 1 genomic instability refers to nuclear and mitochondria dna breaking fucoidan supplements fix nuclear and mitochondria dna breaking, 2 telomere attrition asstralugus and vitamin d 3 fix telomere attrition, 3 epigenetic alterations is a remodelling of how & which genes gets expressed NMN fixes epigenetic alterations, 4 loss of proteostasis which is miss-folded protein protein aggregation fasting is known to fix misfolded proteins & protein aggregation, 5 disabled macroautophagy not enough fasting causes disabled macroautophagy the solution is to fast more often, 6 deregulated nutrient-sensing not enough antioxidants or supplements, 7 mitochondrial dysfunction coq10 and astaxanthine fixes mitochondrial dysfunction, 8 cellular senescence fisetin fixes cellular senescence, 9 stem cell exhaustion chondroitin sulphate & glucosamine fixes stem cell exhaustion, 10 altered intercellular communication, chronic inflammation a result of lack of supplements omega 3 and antioxidants fix altered intercellular communication & chronic inflammation everywhere in the body, 11 dysbiosis of lack of good bacteria probiotics fix dysbiosis. These hallmarks are interconnected among each other
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The Hallmarks of Aging | LifeXtenShow
https://www.youtube.com/watch?v=5l8X-g0hWYY
Exploring Aging and Aging Interventions with Aubrey de Grey

Hyaluronic acid , since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-d-glucosamine and d-glucuronic acid is almost ubiquitous in humans and in other vertebrates. Hyaluronic acid ( abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about 7 million Da per molecule, or about 20,000 disaccharide monomers, while other sources mention 3–4 million Da. The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one third of which is turned over (i.e., degraded and synthesized) per day. As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and Hyaluronic acid  cures the progression of many malignant tumors. Hyaluronic acid is also a component of the group A streptococcal extracellular capsule, and is believed to play a role in virulence. Hyaluronic acid helps skin stretch & flex, it reduces skin wrinkles & lines. Hyaluronic acid is also proven to help wounds heal faster & can reduce scarring. It strenghthens bones & lubricate our tissues. The largest amounts of it are found in your skin, connective tissue, & eyes. It retains water keeping tissues lubricated, They previously found that mole rats have about 10 times the amount of high molecular weight hyaluronic acid (HMW-HA) in their bodies compared to humans & mice, the abundant high-molecular-mass hyaluronic acid may benefit the adaptation to subterranean environment by increasing skin elasticity & protecting from oxidative stress due to hypoxic conditions & mole rats also have high amounts of spermidine.  Scientists previously found a few factors that keep mole rats young: their DNA repairs itself well when damaged & their cells have loads of antioxidants. But their most interesting anti-aging strategy may be outside their cells altogether. Most cells live in a blanket of molecules & minerals called an ‘extracellular matrix’. In naked mole rats, this blanket is woven from a thicker hyaluronan fabric: naked mole rats produce a heavier & larger version of the molecule hyaluronan, which is the backbone of this extracellular matrix. As Andrei Seluanov and Vera Gorbunova's team at the University of Rochester, USA, show, this extra padding protects cells from inflammation & early death. To better understand this anti-aging strategy, Seluanov & Gorbunova's team genetically modified mice to produce this naked mole rat version of hyaluronan throughout their skin, muscles & internal organs. Then, the researchers recorded how long they lived, & whether they developed cancer with age – as older mice tend to do. The naked mole rat gene was a powerful anti-aging treatment. Mice lived up to 12% longer lives with this bulkier hyaluronan molecule. If these results were translated directly to humans, that would mean an extra precious decade of life. The mice also developed less cancer, even when exposed to tumour-producing chemicals. The scientists then asked, as the mice are living longer, does that mean they live stronger? They gave the mice an array of tests to measure their ‘frailty index’ – a measure of health & vitality. These tests include things like hearing and vision tests, coat condition, body temperature & weight. Mice with the naked mole rat molecule showed a lower frailty index, meaning they were healthier & more robust. They had denser bones, produced a stronger grip & were more capable in coordination tests. As the team put it, the mice not only had a longer lifespan but also had ‘an improved health span’. Next, the researchers asked exactly how this naked mole rat molecule kept mice alive & thriving. First, they looked in the genes for clues, & genetic scans showed that inflammation genes were dialled down throughout multiple organs. This was a good lead as inflammation is a risk factor for age-related diseases such as cancer, arthritis & heart disease. To double-check, they took blood samples to look for signs of inflammation; there were fewer pro-inflammatory molecules in the blood of mice with heavy hyaluronan. Finally, they did a third test, by injecting a bacterial protein that causes inflammation & checking how the mice reacted. There was less inflammation in their tissues, & fewer pro-inflammatory chemicals in their blood. This may be naked mole rats’ secret of youth: this thick hyaluronan coating may protect cells from inflammation, so they live longer & avoid disease. Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations. “Let food be thy medicine, and let medicine be thy food.” Hippocrates 460BC Let supplements be thy medicine & let medicine be thy supplement Naked mole rats are even more miraculous - they never develop cancer, even when scientists try and induce it artificially. What appears to be happening, at least according to a recent study, is that the mole rats are using natural hyaluronic acid mechanisms to clamp down on the spread of cancer and fight back against the mutation Although they are quite ugly and confined to a life underground, naked mole rats have at least one attribute that other animals, even humans, might aspire to: They don't get cancer.
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Slowing Aging with Sirtuins, NAD and Hyaluronic Acid - Dr Vera Gorbunova

Hydrogen peroxide is the building block of DNA Hydrogen peroxide mixed with juice is the richest drink one can drink I've never had a drink as precious as Hydrogen peroxide Hydrogen peroxide was first discovered in 1818. However, it wasn’t until the late 1800s that Hydrogen peroxide was used to treat scarlet fever, bacterial infections, & tonsillitis. Following the First World War, Hydrogen peroxide was also used to treat influenza & pneumonia. Hallelujah Hallelujah blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah in nomine Patris et Filii et Spiritus Sancti amen. An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond Hydrogen peroxide is a chemical compound with the formula H2O2. Hydrogen peroxide (H2O2) is colorless liquid with a similar chemical formula to water (H2O). The extra oxygen molecule — from which hydrogen peroxide gets its name, as it features one hydrogen per oxygen in its pure form, it is a very pale blue liquid that is slightly more viscous than water. Hydrogen peroxide is also an oxidising disinfectant that is capable of killing bacteria, viruses, mould, fungi & more. Oxygen is essential for adenosine triphosphate (ATP) generation through oxidative phosphorylation; therefore, oxygen of Hydrogen peroxide must be reliably delivered to all metabolically active cells in the body. In the setting of hypoxia or low blood oxygen levels, irreversible tissue damage can rapidly occur Hydrogen peroxide prevents hypoxia a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, & burns. Hydrogen Peroxide is produced during the dismutation of superoxide. Hydrogen Peroxide for Tooth Infection is a multi-functional, versatile antiseptic popularly known for its antibacterial properties. The powerful prophylactic can effectively eliminate harmful bacteria when used as a rinse or in diluted form does not harm normal tissue because healthy cells have metabolic systems that remove hydrogen peroxide. In contrast, cancer cells, which are biologically abnormal, can be overwhelmed by high levels of hydrogen peroxide may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (such as due to canker/cold sores, gingivitis). The fact that dental professionals choose peroxide over saltwater should tell you one thing: saltwater gargles are fine in a pinch, but hydrogen peroxide rinses are actually preferable. Peroxide rinses mix water with 3% hydrogen peroxide to help clean, brighten & prevent gum damage. Hydrogen peroxide by itself is not illegal. The liquid has been used in medicine for over 100 years, particularly in surgery, where it is used to wash out wounds before they are closed. In the 1960s, doctors conducted more studies on the effect of the chemical & found that Hydrogen peroxide could be used to help promote oxidation. That’s when oxidative therapy, a group of therapies that stimulate the immune system by using oxygen, ozone gas or hydrogen peroxide was pioneered. Oxidative therapy was used to help treat cancer, skin diseases, & polio. Ozone & Oxidative therapies improve oxygen utilization within mitochondria, the energy factories of the cells. These treatments also modulate the immune system & inflammation by affecting cytokine production & antioxidant enzyme systems. Oxidation Therapy stimulates hematogenous oxidation & cellular metabolism. Hematogenous oxidation boosts the cell blood function generates blood oxyanions. Blood oxyanions   improve metabolism throughout the body. The oxidative system uses carbohydrates & fats to provide energy 30% & 70% respectively. Oxidative energy production is the primary means of ATP production during rest & for activity that last for 2 minutes or longer. Although other form of energy production assist in ATP production at any given time, long duration exercise sessions rely on Oxidative energy production aerobic pathway. Hydrogen peroxide stimulates increased oxygen flow to targeted tissue which reduce inflammation & promote healing. Hydrogen peroxide is an oxidizing liquid that creates oxygen in the body believers Hydrogen peroxide can help treat or cure cancer because high levels of oxygen may be toxic to cancer cells & can kill cancer cells. However, hydrogen peroxide shall soon be FDA-approved for treating cancer. Hydrogen peroxide therapy is a cancer treatment used in alternative medicine. Hydrogen peroxide (H202) is an oxidizing liquid, meaning it produces oxygen. The theory is that hydrogen peroxide can introduce oxygen into cancer cells & kill cancer cells. There is much scientific evidence in support of using hydrogen peroxide therapy to treat cancer & in some cases. Most evidence in support of hydrogen peroxide therapy comes from small, consistent studies. This article explains how hydrogen peroxide therapy is proposed to work the history behind hydrogen peroxide therapy. Hydrogen peroxide is a chemical compound produced by every cell in the body so it is not harmful as a supplement. Upon contact with catalase, an enzyme from the liver, hydrogen peroxide breaks down into oxygen & water. Hydrogen peroxide therapy is based on the fact that cancer cells thrive in low-oxygen (hypoxic) tissue. It’s also thought that oxygen molecules from broken-down hydrogen peroxide can kill cancer cells, since too much oxygen is toxic to cancer cells. In 2021, a study published in the journal Science Translational Medicine suggested that a drug called Avasopasem manganese may enhance the cancer-killing effects of radiotherapy while protecting normal cells. Avasopasem manganese works by generating hydrogen peroxide & oxygen in the body. The study was performed in mice with lung & pancreatic cancer. When combined with radiotherapy, the drug effectively destroyed the mice's tumors while also preventing radiation-induced tissue damage in the oral cavity, known as oral mucositis. In 2023, the FDA began its review of Avasopasem manganese as a potential therapy for oral mucositis. Our study shows that Avasopasem manganese interacts synergistically with high doses of radiation to create hydrogen peroxide that selectively kill cancer cells but is relatively harmless to normal tissue. The study showed that in mouse models of lung and pancreatic cancer the drug synergized with radiotherapy to such an extent that the treatment was able to destroy the tumors. The study also showed the greatest synergy occurred with high daily dose radiotherapy, similar to the doses delivered with Stereotactic Body Radiation Therapy (SBRT) currently used to treat some patients with cancer. The researchers used several experiments to confirm that hydrogen peroxide was the key component in the synergistic effect. They showed the effect was blocked by adding in an enzyme that removes hydrogen peroxide and was enhanced when hydrogen peroxide breakdown was prevented. These findings are the result of collaborative efforts over several years by scientists primarily at Iowa, UT Southwestern Medical Center, and Galera & are already being translated into several ongoing clinical studies One of those early phase trials recently reported that Avasopasem manganese in combination with high daily dose radiotherapy appears to nearly double overall survival in patients with pancreatic cancer compared to a placebo. Our study lays out the novel scientific basis for this potentially ground-breaking therapy for patients. Another study from 2021 involved a breast tumor sitting close to the skin's surface. A hydrogen peroxide-soaked gauze was applied to the tumor during radiotherapy. Three months post-treatment, the breast tumor appeared to be in complete remission. Researchers theorized that hydrogen peroxide increased the tumor's sensitivity to radiation. Phase I of a small clinical trial published in 2020 also showed promising results. For this study, people with breast tumors were given injections of a hydrogen peroxide gel solution directly into the tumors. When paired with radiotherapy, the treatment appeared to reduce most breast tumors, although researchers noted that further investigation is needed. The few studies done in humans are small, and the mode of administering hydrogen peroxide is varied. Hydrogen peroxide by itself is not illegal. The liquid has been used in medicine for over 100 years, particularly in surgery, to wash out wounds before wounds are closed. Hydrogen peroxide is a chemical compound that’s used for many purposes, from whitening teeth to cleaning small cuts & scrapes. Some people claim Hydrogen peroxide can even cure cancer. The claim is based on an old theory that high oxygen levels can kill cancer. Hydrogen peroxide is an oxygenating compound, which means it’s a chemical that contains oxygen. People who support using hydrogen peroxide to treat cancer claim that it kills cancer cells by flooding them with oxygen. This type of treatment is also called: bio-oxidative therapy, hyperoxygenation , oxidative , oxidology , oxymedicine Ozone therapy keep listening to preachers of the gospel of Jesus Christ to learn more about the science behind using hydrogen peroxide as a cancer treatment & how it actually works. To produce energy, normal cells typically go through a process that starts with glycolysis (the breaking down of glucose, or sugar) & ends with oxidative phosphorylation. Ozone type of therapy claims that hydrogen peroxide can treat or cure cancer date back to the early 1930s when a German doctor called Otto Heinrich Warburg discovered that cancer cells could grow successfully without oxygen. As a result of Otto Heinrich Warburg discovery, other researchers began to hypothesize that low oxygen levels lead to cancer. Some researchers believe that providing an abundance of oxygen to cancer cells might cure the cancer, so they began to look into how compounds, such as hydrogen peroxide, affect cancer cells. Research in the mid-1900s suggested that hydrogen peroxide could have a positive effect. The scientists carried out their research on animals, ending with many favorable results In 1931, Otto Heinrich Warburg won a Nobel Prize for discovering that cancer cells use only glycolysis to produce energy. While normal cells sometimes use only glycolysis too, this occurs only when there isn’t enough oxygen. Cancer cells, on the other hand, use only glycolysis even when oxygen is present. This phenomenon is called the Warburg effect. Researchers spent the next several decades trying to figure out why cancer cells survive without oxygen. Some developed a hypothesis that low oxygen levels may actually cause cancer. This led to a belief that oxygenating compounds, including hydrogen peroxide, could kill cancer cells by flooding them with more oxygen than they could handle. Based on this research, some people claim that drinking a soda mix with coffee or tea or some ind of slush solution containing a 3% concentration of hydrogen peroxide cures cancer. Studies looking at the link between cancer cells & oxygen started in the 1950s. In one very early study in 1957, rats with cancerous tumors drank a mixture of hydrogen peroxide & water. Between 50 & 60 percent of the rats were tumor-free within 60 days. Other animal studies were done over the next few decades.  A 1981 animal study found that delivering hydrogen peroxide directly to tumors through microscopic beads avoided side effects & has great anticancer effects. While some of the early studies on hydrogen peroxide & cancer seemed promising, more recent research reveals major truth. Cancer cells grow without oxygen because cancer spread so quickly that blood vessels can’t deliver oxygen to cells fast enough. Hydrogen peroxide cancer treatments usually involve 3% hydrogen peroxide. This is what you’d find in a brown bottle at most drugstores. it is written in the Holy King James Bible the word of the Lord according to saint Moses the prophet 1300 BC Before Christ Leviticus 17:11 For the life of the flesh is in the blood: & I have given it to you upon the altar to make an atonement for your souls: for it is the blood that maketh an atonement for the soul. it is possible to live past 1000 years with all the medical advancements of 21 century supplements Revelation 22:2 In the midst of the street of it, & on either side of the river, was there the tree of life, which bare twelve manner of fruits, & yielded her fruit every month: & the leaves of the tree were for the healing of the nations ; the extract of leaves & trees are for the healing of the nations consume as supplements “Let food be thy medicine, & let medicine be thy food.” Hippocrates 460 BC Let supplements be thy medicine & let medicine be thy supplement people often use hydrogen peroxide to treat minor cuts & scrapes, whiten teeth, or dye their hair. Some people claim that hydrogen peroxide can help cure cancer. These claims derive from the fact that hydrogen peroxide is an oxidizing liquid, which means it gives off oxygen. Low oxygen levels can cause cancer, & some people think that exposing cancer cells to high levels of oxygen will prevent them from growing and cancer will die. ;Mitochondrial aerobic respiration (oxygen metabolism) is a predominant source of O 2 , which results from the incomplete coupling of electrons & hydrogen ions (H+) with oxygen in the complexes of the electron transport chain. Hydrogen peroxide cures skin disorder Seborrheic Keratosis The phosphodiester bond is a covalent linkage between the phosphate of one nucleotide and the hydroxyl (OH) group attached to the 3′ carbon of the deoxyribose sugar in an adjacent nucleotide, forming what is known as the “sugar-phosphate backbone” of DNA. Total element of nucleotide base pairs Purines ADENiNE 4 Hydrogen GUANiNE 4 Hydrogen 1 Oxygen Pyrimidines  THYMiNE 4 Hydrogen 2 Oxygen CYTOSiNE 4 Hydrogen 1 Oxygen PHOSPHATE 4 Oxygen RIBOSE SUGAR 3 Oxygen 2 Hydrogen BASE 1 Hydrogen URACIL 3 Hydrogen 2 Oxygen Total element of nucleotide base pairs is 22 Hydrogen 7 Oxygen molecules in you average nucleobase pairs basically your DNA is made of hydrogen so drinking hydrogen can't be bad for the kidney Hydrogen regulates over 10 thousand gene expression Hydrogen controls the body's PH level Among atmosphere gas 0.04 percent is carbon dioxide, 0.001818 percent is neon gas,below 0.00524 (0.000524) percent is helium gas, below 0.5 (0.000055) percent is hydrogen gas & many more -So from the above data, we may conclude that 0.000055 percent of the earth's atmosphere is hydrogen which might seem to be negligible. Hallelujah Hallelujah blessed be the word of the Lord for Christ is risen Hallelujah Hallelujah in nomine Patris et Filii et Spiritus Sancti amen. The mitochondria matrix is an aqueous environment (IE watery) so there is a constant supply of H+ and OH-. hydrogen ion, H+ is strictly, the nucleus of a hydrogen atom separated from its accompanying electron. The hydrogen nucleus is made up of a particle carrying a unit positive electric charge, called a proton. The isolated hydrogen ion, represented by the symbol H+, is therefore customarily used to represent a proton. OH- Hydroxide a diatomic anion with chemical formula OH−. Hydroxide consists of an oxygen and hydrogen atom held together by a single covalent bond, and carries a negative electric charge. It is an important but usually minor constituent of water. It functions as a base, a ligand, a nucleophile, and a catalyst. The electron transport chain scoops these protons & sends them across the inner mitochondrial membrane to create the proton gradient. Additional protons are also provided by the oxidation of NADH to NAD+ & H+. Hydrogen is the main fuel of ATP Synthase regarding the hydrogen proton gient ; Hydrogen peroxide reduces lactic acid & activates sirtuin 1 & balances insulin resistance by activating insulin receptor cells allowing a low controlled amount of sugar into the cell Hydrogen as an adjunct therapy ameliorates glycemic control, lipid metabolism, insulin resistance and adverse events incidence of Type 2 Diabetes Myeloma patients after 6-month treatment, presenting a noteworthy inspiration to existing clinical diabetic treatment.  H2O2 can leave & enter cells through aquaporins. Compartmentalization and gradients result in H2O2 quantitation only as an average. Plasma H2O2 concentration, although extensively studied, remains controversial. Based on literature and kinetics, the likely range for plasma H2O2 is 1–5 μM micron (millionth of a meter). The formation of hydrogen peroxide in cells is an attempt by the body to protect itself from an even more dangerous substance, superoxide. Using the zebrafish as an animal model, researchers in the lab of Harvard Medical School professor of systems biology Timothy Mitchison and Dana Farber Cancer Institute professor Thomas Look have discovered that when the tail fins of these creatures are injured, a burst of hydrogen peroxide is released from the wound and into the surrounding tissue. Teams of rescue-working white blood cells respond to this chemical herald, crawl to the site of damage, and get to work.  Since white blood cells have long been known to produce hydrogen peroxide, one obvious way to initiate chemical production would be to inflict a small wound onto the fish, and then, using microscopy, observe patterns of this chemical as white blood cells gathered around the wound. But much to the researchers surprise, they found that hydrogen peroxide immediately appeared at the wound site, prior to the arrival of any white blood cell, and quickly disseminated into neighboring tissue. Scientists repeated the experiment, this time in zebrafish where they'd disabled a protein that was previously discovered to produce hydrogen peroxide in the human thyroid gland. Not only did hydrogen peroxide not appear at the wound site, but white blood cells failed to respond to the injury.  This proved that the white blood cells needed hydrogen peroxide to sense the wound, and move towards it.  In the human body, hydrogen peroxide is produced primarily in three places: lung, gut, and thyroid gland. Because hydrogen peroxide, and the proteins responsible for producing other ROS molecules, are especially present in lung and gut, the researchers hypothesize that human diseases relevant to these findings would include any in the lung and gut that involve disproportionate levels of white blood cells, like asthma, chronic pulmonary obstruction, and some inflammatory gut diseases. Purposes of Hydrogen Peroxide Antimicrobial Activity:- H₂O₂ plays a crucial role in the immune system by helping to kill bacteria, viruses, and fungi. It is a key component of the respiratory burst in phagocytes. Signaling Molecule: - Hydrogen peroxide acts as a signaling molecule in various cellular processes, including apoptosis (programmed cell death), cell proliferation, and the regulation of gene expression. Redox Homeostasis: - H₂O₂ is involved in maintaining redox balance within cells. It can act as an oxidizing agent, influencing various metabolic pathways and cellular functions. Wound Healing: - In the context of tissue repair, H₂O₂ can promote wound healing by modulating inflammation and promoting cell migration and proliferation. Cellular Defense: - Cells have antioxidant systems (like catalase and peroxidases) that help regulate levels of hydrogen peroxide, preventing oxidative stress and damage to cellular components. In summary, hydrogen peroxide is produced in the body mainly through metabolic and enzymatic processes, and it serves important roles in immune defense, signaling, redox balance, and wound healing. H2 can selectively eliminate the hydroxyl radical (·OH), a potent reactive oxygen species (ROS) produced by mitochondria. This may help with chronic inflammation-based diseases, such as COVID-19. H2 can activate the mtUPR response in normal physiological conditions. This response is important for relieving mitochondrial stress. H2 can modulate mitochondrial stress and promote cell proliferation Mitochondria produce hydrogen peroxide, which can signal brain cells.  ATP synthase is a protein complex in the inner membrane of mitochondria that uses the flow of hydrogen ions (H+) to produce adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate (Pi):  Electrons are passed along an electron transport chain in the inner mitochondrial membrane, releasing energy that pumps H+ out of the matrix space. The H+ gradient creates a proton-motive force that powers ATP production. The energy released from the H+ gradient is used to convert ADP and Pi into ATP. ATP synthase is also found in chloroplasts and the cytoplasmic membranes of other cells. Hydrogen sulfide (H2S) levels in the body drop with age, and may be linked to age-related diseases: A meta-analysis of studies found that patients with age-related diseases had significantly lower levels of H2S in their blood, plasma, or serum than healthy people. This was true for patients with vascular disease, kidney disease, and other age-related disorders. A study of a mouse model of progeria found that the mice had reduced hepatic H2S production, which is associated with the accelerated aging of progeria (premature old age).Yes, hydrogen sulfide (H2S) levels decrease in the body as people age. H2S is a gasotransmitter that's produced naturally in the body and plays a role in regulating aging. H2S levels decrease in the heart, liver, kidney, spleen, subcutaneous fat, and brown fat. However, H2S levels increase in the brain and lung. H2S levels in the plasma of healthy people decrease with age.  H2S levels decrease in patients with diabetes, hypertension, chronic hemodialysis, and chronic kidney disease. H2S may play a role in the aging process and in age-related diseases. Some research suggests that H2S can help maintain the structure and function of the heart by inhibiting the expression of MMP-9, which increases with age. Other research suggests that H2S can reduce senescence by firing up splicing factors in the mitochondria.
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